Publications


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2018

Rao-Ruiz, Priyanka et al. Neuronal competition: microcircuit mechanisms define the sparsity of the engram. Curr. Opin. Neurobiol., 54.
Josselyn, Sheena A. The past, present and future of light-gated ion channels and optogenetics. Elife, 7.
Josselyn, Sheena A, Frankland, Paul W. Fear Extinction Requires Reward. Cell, 175, 3, 639-640.
Ramsaran, Adam I et al. The ontogeny of memory persistence and specificity. Dev Cogn Neurosci.
Xia, Frances, Frankland, Paul W. Cognitive Neuroscience: Exciting Developments in Schematic Learning. Curr. Biol., 28, 18, R1096-R1098.
Syal, Charvi et al. Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age. Sci Rep, 8, 1, 13489.
Sekeres, Melanie J et al. Impaired recent, but preserved remote, autobiographical memory in pediatric brain tumor patients. J. Neurosci..
Guskjolen, Axel et al. Recovery of 'Lost' Infant Memories in Mice. Curr. Biol., 28, 14, 2283-2290.e3.
Kramer, Emily E et al. Assessing Individual Neuronal Activity Across the Intact Brain: Using Hybridization Chain Reaction (HCR) to Detect Arc mRNA Localized to the Nucleus in Volumes of Cleared Brain Tissue. Curr Protoc Neurosci, 84, 1, e49.
Jacob, Alexander D et al. A Compact Head-Mounted Endoscope for In Vivo Calcium Imaging in Freely Behaving Mice. Curr Protoc Neurosci, 84, 1, e51.
Frankland, Paul W, Josselyn, Sheena A. Facing your fears. Science, 360, 6394, 1186-1187.
Miller, Adam M P et al. Memory: Ironing Out a Wrinkle in Time. Curr. Biol., 28, 10, R599-R601.
Josselyn, Sheena A, Frankland, Paul W. Memory Allocation: Mechanisms and Function. Annu. Rev. Neurosci., 41.
Kempermann, Gerd et al. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23, 1, 25-30.
Gao, Aijing et al. Elevation of Hippocampal Neurogenesis Induces a Temporally Graded Pattern of Forgetting of Contextual Fear Memories. J. Neurosci., 38, 13, 3190-3198.

2017

Xia, Frances et al. Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation. Elife, 6.
Kenney, Justin W et al. Contextual fear conditioning in zebrafish. Learn. Mem., 24, 10, 516-523.
Richards, Blake A, Frankland, Paul W. The Persistence and Transience of Memory. Neuron, 94, 6, 1071-1084.
Xia, Frances et al. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology, 42, 13, 2493-2503.
Snyder, Jason S et al. Running promotes spatial bias independently of adult neurogenesis. Hippocampus, 27, 8, 871-882.
Josselyn, Sheena A et al. Heroes of the Engram. J. Neurosci., 37, 18, 4647-4657.
Vetere, Gisella et al. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice. Neuron, 94, 2, 363-374.e4.
Tanimizu, Toshiyuki et al. Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory. J. Neurosci., 37, 15, 4103-4116.
Walters, Brandon J et al. The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. Neuropsychopharmacology, 42, 7, 1502-1510.

2016

Guskjolen, Axel et al. Age-dependent changes in spatial memory retention and flexibility in mice. Neurobiol Learn Mem, 143.
Santoro, Adam et al. Memory Transformation Enhances Reinforcement Learning in Dynamic Environments. J. Neurosci., 36, 48, 12228-12242.
Walters, Brandon J et al. Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain. Front Genet, 6.
Yang, Guang et al. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep, 17, 4, 1022-1036.
Ishikawa, Rie et al. Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval. Elife, 5.
Epp, Jonathan R, Frankland, Paul W. Re-engineering the Hippocampus. Neuron, 91, 6, 1190-1191.
Gouveia, Ayden et al. The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner. Stem Cell Reports, 7, 4, 719-734.
Rashid, Asim J et al. Competition between engrams influences fear memory formation and recall. Science, 353, 6297, 383-7.
Morrison, Dano J et al. Parvalbumin interneurons constrain the size of the lateral amygdala engram. Neurobiol Learn Mem, 135.
Frankland, Paul W, Josselyn, Sheena A Neuroscience: In search of the memory molecule. Nature, 535, 7610, 41-2.
Park, Sungmo et al. Neuronal Allocation to a Hippocampal Engram. Neuropsychopharmacology, 41, 13, 2987-2993.
Ramsaran and Frankland The young and the promiscuous. Neuron, 90, 6-8. (PDF)
Epp et al. Neurogenesis-mediated forgetting minimizes proactive interference. Nature Communications, 7:10838. (PDF)
Chakravarty et al. Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature. Neuroimage, 125, 422-427. (PDF)
Frankland and Josselyn Hippocampal neurogenesis and memory clearance. Neuropsychoparmacology, 41, 382-383. (PDF)

2015

Ali, Ahmed M et al. Optogenetic Inhibitor of the Transcription Factor CREB. Chem. Biol., 22, 11, 1531-1539.
Ehrlich, D E, Josselyn, S A. Plasticity-related genes in brain development and amygdala-dependent learning. Genes Brain Behav., 15, 1, 125-43.
Adamantidis, Antoine et al. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat. Neurosci., 18, 9, 1202-12.
Wong, Albert H C, Josselyn, Sheena A. Caution When Diagnosing Your Mouse With Schizophrenia: The Use and Misuse of Model Animals for Understanding Psychiatric Disorders. Biol. Psychiatry, 79, 1, 32-8.
Berndt et al. Channelrhodopsin pore engineering: second-generation chloride channels and the structural determinants of ion flux. PNAS, in press. (PDF)
Scholz et al. Rotarod training in mice is associated with changes in brain structure observable with multimodal MRI. Neuroimage, 107, 182-189. (PDF)
Epp et al. Optimization of CLARITY for clearing whole brain and other intact organs. eNeuro, 2(3) e0022-15.2015 1–15. (PDF)
Josselyn et al. Finding the engram. Nature Reviews Neuroscience, 16, 521-534. (PDF)
Restivo et al. Development of adult-generated cell connectivity with excitatory and inhibitory cell populations in the hippocampus. Journal of Neuroscience, 35, 10600-12 (PDF)
Vousden et al. Mechanism, function, and computation in neural systems. Behavioural Processes, 117, 4-11. (PDF)

2014

Josselyn and Frankland A new twist in the histone memory code. Cell Research, 25, 151-152. (PDF)
Allemang-Grand, R et al. Altered brain development in an early-onset murine model of Alzheimer's disease. Neurobiol. Aging, 36, 2, 638-47.
Vieira, Philip A et al. Prefrontal consolidation supports the attainment of fear memory accuracy. Learn. Mem., 21, 8, 394-405.
Insel and Frankland Mechanism, function, and computation in neural systems. Behavioural Processes, 117, 4-11. (PDF)
Turnbull et al. PTG depletion rescues malin-deficient Lafora disease in mouse. Annals of Neurology, 75, 442-6. (PDF)
Arruda-Carvalho et al.14b). Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories. Journal of Neuroscience, 34, 15793-803. (PDF)
Santoro and Frankland Chasing the trace. Neuron, 84, 243-245. (PDF)
Hsiang et al. Manipulating a cocaine memory trace in mice. Journal of Neuroscience, 34,14115-27. (PDF)
Arruda-Carvalho et al. Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. Journal of Neuroscience, 34, 11919-28. (PDF)
Yiu, Mercaldo et al. Neurons are recruited to a memory trace based on relative neuronal excitability at the time of training. Neuron, 83, 722-35. (PDF)
Richards et al. Patterns across multiple memories are identified over time. Nature Neuroscience, 17, 981-6. (PDF)
Akers, Martinez-Canabal, Restivo et al. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science, 344, 598-602. (PDF)

2013

Sargin et al. Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiology of Learning and Memory, 103, 39-49. (PDF)
Sargin et al. CREB regulates spine density of lateral amygdala neurons: implications for memory allocation. Frontiers in Behavioral Neuroscience, 7, 209. (PDF)
Turnbull et al. Deficiency of a Glycogen Synthase-associated Protein, Epm2aip1, Causes Decreased Glycogen Synthesis and Hepatic Insulin Resistance. Journal of Biological Chemistry, 288(48), 34627-37. (PDF)
Rashid, A J et al. Emerging roles for MEF2 transcription factors in memory. Genes Brain Behav., 13, 1, 118-25.
Wasserman, David I et al. Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites. Eur. J. Neurosci., 38, 5, 2774-85.
Sengar, Ameet S et al. Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. J. Neurosci., 33, 9, 4055-65.
Pederson et al. Inhibiting glycogen synthesis prevents lafora disease in a mouse model. Annals of Neurology, 74, 297-300. (PDF)
Frankland et al. Hippocampal neurogenesis and forgetting. Trends in Neuroscience, 36, 497-503. (PDF)
Josselyn and Frankland. mTORC2: actin on your memory. Nature Neuroscience, 16, 379-380. (PDF)
Frankland. Neurogenic evangelism. Behavioral Neuroscience, 127, 126-129. (PDF)
Richards and Frankland. The conjunctive trace. Hippocampus, 23, 207-212. (PDF)
Wheeler et al. Adolescent cocaine exposure causes enduring macroscale changes in brain structure. Journal of Neuroscience, 33, 1797-1803. (PDF)
Wheeler et al. Identification of a functional connectome for long-term fear memory in mice. PLoS Computational Biology, 9(1): e1002853 (PDF)
Frankland and Josselyn. Memory and the single molecule. Nature, 493, 312-3 (PDF)
Martinez-Canabal et al. Chronic over-expression of TGFβ1 alters hippocampal structure and causes spatial learning deficits. Hippocampus, 23, 1198-1211. (PDF)
Cancino et al. p63 regulates adult neural precursor and newly-born neuron survival to control hippocampal-dependent behavior. Journal of Neuroscience, 33, 12569-85. (PDF)
Martinez-Canabal et al. Age-dependent effects of hippocampal neurogenesis suppression on spatial learning. Hippocampus, 23, 66-74. (PDF)
Kim, Jieun et al. Memory recall and modifications by activating neurons with elevated CREB. Nat. Neurosci., 17, 1, 65-72.
Cowansage, Kiriana K et al. Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory. Proc. Natl. Acad. Sci. U.S.A., 110, 41, 16645-50.

2012

Sekeres et al. Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. Journal of Neuroscience, 32, 17857-17868. (PDF)
Niibori et al. Suppression of adult neurogenesis impairs population coding of similar contexts in the hippocampal CA3 region. Nature Communications, 3, 1253. (PDF)
Akers et al. The ontogeny of fear memory formation, specificity and persistence in mice. Learning and Memory, 19, 598-604. (PDF)
Gu et al. Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nature Neuroscience, 15, 1700-6. (PDF)
Salih, Dervis A M et al. FoxO6 regulates memory consolidation and synaptic function. Genes Dev., 26, 24, 2780-801.
Mansouri, Alireza et al. Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiol. Dis., 47, 2, 201-9.
Josselyn and Frankland. Infantile amnesia: A neurogenic hypothesis. Learning and Memory, 19, 423-433. (PDF)
Cole et al. MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nature Neuroscience, 15, 1255-64. (PDF)
Wang et al. Metformin activates atypical PKCs to promote rodent and human neurogenesis and enhances hippocampus-dependent learning. Cell Stem Cell, 11, 23-35. (PDF)
Girard et al. Phosphorylation Prevents Polyglucosan Transport: Implications on Lafora Disease. Neurology, 79, 100-102. (PDF)

2011

Arruda-Carvalho et al. Posttraining ablation of adult-generated neurons degrades previously acquired memories. (PDF)
Stone et al. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. (PDF)
Sakaguchi et al. Impaired spatial and contextual memory formation in galectin-1 deficient mice. (PDF)
Leslie et al. Impact of early adverse experience on complexity of adult-generated neurons. (PDF)
Akers et al. Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. (PDF)
Vetere et al. Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. (PDF)
Lerch et al. Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning. (PDF)
Stone et al. Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory. (PDF)

2010

Sekeres et al. Dorsal hippocampal CREB is both necessary and sufficient for spatial memory.
Akers et al. Functional Contribution of Adult-Generated Olfactory Bulb Interneurons: Odor Discrimination versus Odor Memory. (PDF)
Restivo and Frankland Shifting to automatic (PDF)
Bae, James J et al. Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus. Int J Physiol Pathophysiol Pharmacol, 3, 1, 9-20.
Josselyn, Sheena A. Continuing the search for the engram: examining the mechanism of fear memories. J Psychiatry Neurosci, 35, 4, 221-8.

2009

Nai, Qiang et al. Uncoupling the D1-N-methyl-D-aspartate (NMDA) receptor complex promotes NMDA-dependent long-term potentiation and working memory. Biol. Psychiatry, 67, 3, 246-54.
Maei et al. Development and validation of a sensitive entropy-based measure for the water maze. (PDF)
Winocur et al. Manipulating context-specificity in a memory reconsolidation paradigm: Selective effects of hippocampal lesions. (PDF)
Akers et al. Gradients graded: Evidence for time-dependent memory reorganization in experimental animals. (PDF)
Han et al. Selective erasure of a fear memory. (PDF)
Maei et al. What is the most sensitive measure of water maze probe test performance? (PDF)
Wang et al. The precision of remote contextual memories does not require the hippocampus. (PDF)
Mamiya et al. Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory. (PDF)

2008

Liu et al. Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.
Frankland and Miller Regenerating your senses: multiple roles for neurogenesis in the adult brain. (PDF)
Wetzel et al. p73 haploinsufficiency causes age-related neurodegeneration and aberrant tau filament formation. (PDF)
Frankland et al. Starting at the endophenotype: A role for α-CaMKII in schizophrenia? (PDF)
Frankland and Nader From eIF2alpha to Ebbinghaus. (PDF)
Suzuki et al. Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories. (PDF)
Ding et al. Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory. (PDF)

2007

Frankland et al. Grading the gradient: Evidence for time-dependent memory reorganization in experimental animals. (PDF)
Kee, Teixeira, Wang et al. Imaging activation of adult-generated granule cells in spatial memory. (PDF)
Kee, Teixeira et al. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. (PDF)

2006

Frankland et al. Stability of recent and remote contextual fear memory. (PDF)
Teixeira et al. Involvement of the anterior cingulate cortex in the expression of remote spatial memory. (PDF)
Frankland and Bontempi. Fast track to the medial prefrontal cortex. (PDF)

2005

Li et al. The HMG-CoA reductase inhibitor, lovastatin, reverses the learning and attention deficits in a mouse model of Neurofibromatosis Type 1. (PDF)
Josselyn, Sheena A et al. The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior. Neuropsychopharmacology, 30, 1, 17-26.
Tohmi et al. Distinct influences of neonatal epidermal growth factor challenge on adult neurobehavioral traits in four mouse strains. (PDF)
Frankland and Bontempi. The organization of recent and remote memory. (PDF)
Frankland and Teixeira. A pain in the ACC. (PDF)

2004

Suzuki et al. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. (PDF)
Frankland et al. Consolidation of CS and US representations in associative fear conditioning. (PDF)
Frankland et al. Sensorimotor-gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice.
Frankland, Bontempi et al. The involvement of the anterior cingulate cortex in remote contextual fear memory. (PDF)
Josselyn, S A et al. Inducible repression of CREB function disrupts amygdala-dependent memory. Neurobiol Learn Mem, 82, 2, 159-63.

2003

Bozon, Bruno et al. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 358, 1432, 805-14.

2002

Silva, Alcino J, Josselyn, Sheena A. The molecules of forgetfulness. Nature, 418, 6901, 929-30.